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Revolutionary and affordable genetic test kit identifies more than 360 DNA items

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The search for our identities—where we came from, what we’re made of—is a unifying human experience, and our collective fascination with ourselves as individuals has fueled a booming industry around personal DNA testing. Once difficult and expensive even for the most technologically advanced labs, genetic testing is fast becoming a cheap and easy consumer product. More than 12 million people have had their DNA tested by different companies, and that number is expected to grow substantially in the next few years. With a little spit and 200 dollars, you can find out your risk for everything from cystic fibrosis to lactose intolerance.

What Can I Find Out with my DNA test?

Any type of genetic testing, from the consumer-based kits that anyone can buy to the versions that doctors order, can only glean so much information from your DNA. Medical conditions like cancer and heart disease are complex and not likely to be traced to a single aberration in DNA. However, there are some genetic variants that do link to a stronger chance for certain conditions. In those cases, having the genetic change doesn’t ensure that you will develop the condition, but could mean that you have a higher chance of getting the disease.

To sort that out, a Spanish company has created its own unique chip that is able to identify more than 360 information items in the DNA, among which is the susceptibility to polygenic or complex diseases, the diagnosis of monogenic diseases, pharmacogenetic information and phenotypic traits. Thanks to this incorporation of exact biomarkers, the result of the TellmeGen’s DNA test is a 28% more accurate system, compared to than offered by other companies such as the american ‘23andMe’. This makes it a revolutionary DNA test because it offers the analysis of more items at a lower price. The goal of TellmeGen is to provide access to genetic information to people from anywhere in the world. In order to do so, they have developed a platform to store, interpret and update the genetic information when new mutations are discovered. TellmeGen is currently studying more than 555,000 mutations, and they provide this new and updated information at no additional cost.

How Does It Work?

After extracting DNA from your cheek swab or saliva sample, DNA testing companies search your DNA for certain genetic variants. The building blocks of DNA are chemical bases called nucleotides, which come in four varieties—A, T, C, and G (adenine, thymine, cytosine, and guanine, respectively). We have 3 billion pairs of these bases, so 6 billion letters in all, strung together in a sequence. Altogether, this genetic information is called your genome.

DNA testing companies determine which of the four letters is present at many locations in your genome. Much of the sequence is shared among humans, so the companies focus on specific letters that vary from person to person, known as single nucleotide polymorphisms (SNPs). Many SNPs have some biological relevance. For example, having one variant of a specific SNP near the gene OCA2, which codes for a protein believed to be involved in producing the dark pigment melanin, makes it much more likely you’ll have blue or green eyes. Other traits and even some diseases are also associated with certain SNPs, some more strongly than others.

The pioneering technology behind TellmeGen’s system is the genotyping chip, which is then analyzed in the sequencers of their many laboratories spread throughout Europe and Latin America. Thus, the system is based on scientific evidence and reaches 99.99% reliability. To get their DNA tested, all the user has to do is putting a sample of his saliva in the tube that arrives at home inside the TellmeGen Kit box and send it back to the company. You can get the DNA test on Amazon.com. Four to six weeks later, the client receives an electronic notification that his health map is already available online. In addition to the genetic information, each item in the genetic map is associated with the latest recommendations on health prevention. The users also have access to a free public forum where they can interact with medical professionals to interpret their results, and they can also hire the services of a specialist for a better interpretation of the results in an individual consultation.

How Much Does It Cost?

The idea of knowing our health’s risks in advance to be able to prevent diseases is always appealing, but the real question is: how much does a DNA test cost? TellmeGen wanted make genetic health maps affordable to everyone, and in order to do so they based their strategy on adjusting the costs. After years of previous study and analysis, they finally managed to launch TellmeGen DNA test kit, which reduces the average 3,500€ price to 199$, greatly improving the ratio items / price of any other market test.

Plus, the analysis offers four types of results in a single analysis for the same price: risk of the most common diseases, monogenic diseases, pharmacology and personal traits. In addition, in a few weeks ‘Ancestry’ will also be offered for the same price. Customers who used the kit prior to this will not have to pay more, as the results will automatically be updated for free.

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How To Help Reduce Stress In Life

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Keeping out stress from your life is easier said than done. There are a lot of things in life that can make you feel under pressure or gives you that feeling of being overwhelmed. However, you can take control of some of these situations, so here are a few tips on helping reduce stress in your life.

Take Time Out For Yourself

Taking time out is essential and something that will certainly help you feel more like yourself and less like a robot. We can move through life feeling like we’re doing the same things day in and day out. Eat, work, sleep, and repeat. But that can be changed if you make more time for yourself. Stop putting others before you and every so often, perhaps once or twice a week, try and give yourself an hour or even an afternoon to yourself. Whatever time you can spare, no matter how busy you get, do something for you. It can help change the way you feel about your life currently, but more importantly, it helps bring you a little calm and peacefulness in your life, just like https://www.tprf.org/prem-rawat/ mentions.

Eat Well And Exercise

Exercise and eating well are essential to reducing stress levels because sometimes what we eat and do to our body can shift how we’re feeling on the inside for the better. Think about what you’re eating currently and how you can change that in order to feel better about yourself. Try to incorporate more fruit and vegetables as a rule and cut out things that are maybe doing more harm than good for your body. It doesn’t mean you can’t treat yourself every now and then, though. Make sure you’re exercising each day, too, even if it’s walking up the stairs to your office every day. Getting blood and heart pumping is important and can help with stress.

Find Your Guidance

Guidance is something we all need at points in our lives. It helps us find a route to a problem we’re having or to navigate ourselves out of a bad place. Finding that guidance is important, whether it’s through a self-help book, speaking to a friend, or visiting a professional. Find your guidance that will help you focus on how to reduce stress in both a physical and mental way.

Give Your Mind A Reality Check

Finally, when we’re feeling stressed, we can often feel a lot worse than what we should be feeling, and that’s because our minds tend to make the situation ten times worse. So when it comes down to it, it’s important to focus on the positives and to remember the good things that you have in your life. Stress can sometimes overshadow that and make us forget how good we have it sometimes, even if it’s only something small, it’s significant.

Reducing stress in your life is a life-long battle for all of us, but a few tips like these can help minimize the overall stress we feel in life.

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Electrospinning: the most advanced method of drug delivery

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At the pharmaceutical level, the need to improve and refine the methods of drug delivery in the body is an area of great importance. Unlike people commonly assume, the effectiveness of a drug is not based solely on its composition, but on its method of application. 

This fact becomes clear if we look at the different presentations that a drug can have regarding ways of being supplied. Likewise, in the creation and composition of the drug for therapeutic use, the best and most efficient ways of providing the treatment are evaluated. 

The need for a drug delivery system that controls and directs the active pharmaceutical ingredients is becoming increasingly evident to achieve a decrease in the adverse side effects of treatment. An example, the need for control in the release of drug’s API into the body is what happened to cancer patients.

The treatment against cancer is hugely abrasive to the patient’s body, and therefore, its administration must be strongly dosed to decrease the intensity of the adverse side effects in the person. However, this also reduces the effectiveness of the treatment.

Delivery directed specifically to the area of the tumour, increasing the effectiveness of the drug and reducing adverse effects. Different methods of encapsulation have been tested but have marked limitations that allow only reduced variables to be controlled, such as the speed of drug delivery to the body once ingested.

The technology of electrospinning drug delivery breaks with the limitations of the previous methods of encapsulation achieving a controlled, directed and even programmed administration in the body. These benefits are due to the variety of materials that can be processed by electrospinning and the structural variations of the capsules, creating a significant variety for drug delivery in the body. 

What is electrospinning

Electrospinning is a fibre manufacturing technique. It works with electromagnetic principles by subjecting substances to high voltages to generate an electrostatic charge in the material that ends up resulting in the formation of the nanometer fibre as a product of electrostatic repulsion and surface tension of the solution.

Electrospinning has several uses because of its property of being able to produce a great variety of fibres with significant differences from each other without changing the method. Although it was initially used for the manufacture of textiles has expanded to other areas such as the manufacture of batteries. Even combine the fibres with building elements such as concrete because of its high strength due to mechanical stress that is subjected to the material in its manufacture.

However, it is in the area of nanomaterial production where its maximum utility is highlighted since nanomaterials present particular interactions depending on the material, and it is at such scale where cellular processes occur. This reason is why medicine, more specifically pharmacology, benefits greatly from such technology. 

In pharmacology, two types of drugs are sold (differentiated by application according to the fibre), dressings and tissues, both of which can be manufactured with the production of fibres derived from electrospinning. 

Differences between electrospinning and other methods for drug delivery

Notable drug encapsulation methods include spray-drying, freeze-drying and emulsification, which are easily recognizable on sight since most consumer drugs are distributed in such presentations. Each one has his own characteristics that make it more suitable for one type of drug than another, and each one has its limitations.

These methods are based on the preservation and dosage of the drug. Such as freeze-drying, which is the procedure of preservation by cryodrying, or emulsification, which consists of mixing immiscible liquids. While such forms of encapsulation work efficiently to preserve the drug and deliver it to the body, their reach goes there. 

Electrospinning systems for drugs delivery work in two ways, by mixing the bioactive compound, i.e. the drug with the polymer solution before applying electrospinning or after the creation of the fibre by coaxial processing. This method allows the efficient supply of the drug’s API as it benefits from the surface-volume area due to the dependence on the surface area where the application of nanofibers is favoured. 

The drug release profiles are highly adaptable to various applications by varying the solution of the polymer with which the nanofiber is created and controlling its area and volume. This process will allow the distribution of drugs that are released in response to chemical stimuli even hours after they have been ingested, that target specific areas if created with magnetic components, and even facilitate their production on a large scale since the other methods find it difficult to produce them massively.Innovation in fibre production in the pharmacological area will create more significant and more efficient scope for the medication of many diseases, improving the treatment of the patient and increasing its effectiveness. Electrospinning technology admits a wide range of natural and synthetic polymers for processing, in turn, lowers production costs, allowing for greater distribution of medicines to various sectors of the population.

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Things that you need to consider before having a lumbar disk replacement surgery

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In the world are many people who have difficult or problem with their spine. For that reason, is very common to see people having a lumbar disk replacement surgery recovery, after having had an intervention in the operating room to improve their health conditions. This kind of surgery usually doesn’t represent a risk for patients, but sometimes is necessary to know aspects that need to be considered before having this surgery.

A surgery is needed?

Spine problems can generate pain and make people have an unhealthy posture. This makes necessary to solve any problem associated with it to have a great life condition and to avoid any risk associated with spine diseases. Unfortunately there are many people who, for one reason or another, need an intervention in the operating room, due to the wear on their spine

Is a solution to many spine problems that could be generating difficulties or pain to patients. Recovery from lumbar disc replacement surgery requires that the patient receive rehabilitation for a few months for optimal results. This surgery has a fast recovery and doesn’t represent any risk of having it. It is a way to ensure the recovery of the spine; even about 80% of people can return to sports.Therefore, it’s normal that professionals recommend it as the first way to cure any disease related to the spine.

Despite all this, there are some indications or information that people need to know before having a lumbar disk replacement surgery. This will make the patient be more confident about this surgery and will make them to pass all this process with no difficulty. 

Here you will find full information about some things that need to be present before having this type of surgery. This will be essential to have the best process and have a fast surgery recovery.

What kind of things are necessary to consider before having a lumbar disk replacement surgery?

The degeneration of the parts of the spine can cause many health problems that, in the long run, they can bring serious health diseases. Therefore, having a lumbar disk replacement will be beneficial to patients. Despite this, is recommended to consider some aspects before decide or not to have this type of surgery.

Some main aspects that you need to think about before having this type of surgeries, are:

  • Find the best center: it’s necessary to consider many spine centers that can do this surgery with no problem. Also, is recommended to compare all options to determine which will be the best for your needs. This will help you in the surgery recovery and to avoid any possible risk.
  • Collect any information about the surgery: it’s indispensable to collect all the information about this surgery. For example, any risk, costs, recovery plan and the knowing about if this replacement will fix any health problem or disease.
  • Determine the quality of the artificial lumbar disc: it’s necessary to know the quality of the object that will be used on the surgery. This will understand any possible risk using this artificial product and will let you know if is the best option at this moment.
  • Ask for not intrusive solutions: if you have any problem with the lumbar disk or the spine, it’s recommended to have a not intrusive treatment, instead of having a surgery or disk replacement. Therefore, try to only have surgery at the last option. 
  • Find a plan of recovery and prevention: have a lumbar disk replacement has its problems and risk. Therefore, always it’s recommended to follow some recommendations and plans to keep your spine healthy. All this can be determined by a professional in this area, which will give you the correct information and indications about the after surgery treatment. 
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