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Electrospinning: the most advanced method of drug delivery

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electrospinning drug delivery

At the pharmaceutical level, the need to improve and refine the methods of drug delivery in the body is an area of great importance. Unlike people commonly assume, the effectiveness of a drug is not based solely on its composition, but on its method of application. 

This fact becomes clear if we look at the different presentations that a drug can have regarding ways of being supplied. Likewise, in the creation and composition of the drug for therapeutic use, the best and most efficient ways of providing the treatment are evaluated. 

The need for a drug delivery system that controls and directs the active pharmaceutical ingredients is becoming increasingly evident to achieve a decrease in the adverse side effects of treatment. An example, the need for control in the release of drug’s API into the body is what happened to cancer patients.

The treatment against cancer is hugely abrasive to the patient’s body, and therefore, its administration must be strongly dosed to decrease the intensity of the adverse side effects in the person. However, this also reduces the effectiveness of the treatment.

Delivery directed specifically to the area of the tumour, increasing the effectiveness of the drug and reducing adverse effects. Different methods of encapsulation have been tested but have marked limitations that allow only reduced variables to be controlled, such as the speed of drug delivery to the body once ingested.

The technology of electrospinning drug delivery breaks with the limitations of the previous methods of encapsulation achieving a controlled, directed and even programmed administration in the body. These benefits are due to the variety of materials that can be processed by electrospinning and the structural variations of the capsules, creating a significant variety for drug delivery in the body. 

What is electrospinning

Electrospinning is a fibre manufacturing technique. It works with electromagnetic principles by subjecting substances to high voltages to generate an electrostatic charge in the material that ends up resulting in the formation of the nanometer fibre as a product of electrostatic repulsion and surface tension of the solution.

Electrospinning has several uses because of its property of being able to produce a great variety of fibres with significant differences from each other without changing the method. Although it was initially used for the manufacture of textiles has expanded to other areas such as the manufacture of batteries. Even combine the fibres with building elements such as concrete because of its high strength due to mechanical stress that is subjected to the material in its manufacture.

However, it is in the area of nanomaterial production where its maximum utility is highlighted since nanomaterials present particular interactions depending on the material, and it is at such scale where cellular processes occur. This reason is why medicine, more specifically pharmacology, benefits greatly from such technology. 

In pharmacology, two types of drugs are sold (differentiated by application according to the fibre), dressings and tissues, both of which can be manufactured with the production of fibres derived from electrospinning. 

Differences between electrospinning and other methods for drug delivery

Notable drug encapsulation methods include spray-drying, freeze-drying and emulsification, which are easily recognizable on sight since most consumer drugs are distributed in such presentations. Each one has his own characteristics that make it more suitable for one type of drug than another, and each one has its limitations.

These methods are based on the preservation and dosage of the drug. Such as freeze-drying, which is the procedure of preservation by cryodrying, or emulsification, which consists of mixing immiscible liquids. While such forms of encapsulation work efficiently to preserve the drug and deliver it to the body, their reach goes there. 

Electrospinning systems for drugs delivery work in two ways, by mixing the bioactive compound, i.e. the drug with the polymer solution before applying electrospinning or after the creation of the fibre by coaxial processing. This method allows the efficient supply of the drug’s API as it benefits from the surface-volume area due to the dependence on the surface area where the application of nanofibers is favoured. 

The drug release profiles are highly adaptable to various applications by varying the solution of the polymer with which the nanofiber is created and controlling its area and volume. This process will allow the distribution of drugs that are released in response to chemical stimuli even hours after they have been ingested, that target specific areas if created with magnetic components, and even facilitate their production on a large scale since the other methods find it difficult to produce them massively.Innovation in fibre production in the pharmacological area will create more significant and more efficient scope for the medication of many diseases, improving the treatment of the patient and increasing its effectiveness. Electrospinning technology admits a wide range of natural and synthetic polymers for processing, in turn, lowers production costs, allowing for greater distribution of medicines to various sectors of the population.

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Student @ Advanced Digital Sciences Center, Singapore. Travelled to 30+ countries, passion for basketball.

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Putting your health on the best hands

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Our background can affect our priorities in life. For example, some people want to travel while others prefer to stay at home with their love ones. But if there is something that everybody should always be a priority no matter what, it is our health. Our health should always be the most important aspect in our lives, therefore, we always need to prioritize having access to the best health services to look after it. 

Having access to the best health services

Health is one of the most important things in life. Becoming sick can have a detrimental effect on our lives, and, in severe cases, receiving the proper treatment as soon as possible can mark the difference between life and death. Therefore, when we sign for a health service, we need to make sure that we will have access to the best professionals in the sector and the best facilities. 

This also extends to health services when we travel abroad. Over the last decades, Marbella has become a popular holiday destination and a trendy place for expats to start a new life. This southern Spanish town seems to have everything you could wish for, including which is probably the best private clinic in the country. 

Spanish public health system may seem flawless sometimes, especially if we expect a quick response to our health problems. Therefore, checking out for a Marbella private clinic during your stay is, by far, the smarter option.

A private clinic that has become renown, not only in Marbella  but on the entire country, for the excellent quality of the services they provide is Excelan. 

Excelan was especially designed keeping the needs of foreign patients in mind. Their team will provide you with multilingual assistance 24 hours a day, 365 days a year. 

But the services Excelan provides to their patients go way beyond the language. Excelan has its own fleet of private ambulances. Excelan has the latest models of ambulances to ensure safe, fast and comfortable transfers, all fully equipped with the latest technology to take care of the patient. A good example of Excelan being the smarter choice is that their ambulances are equipped with a hydro-pneumatic bench system (a system that absorbs the vibrations or sudden movements that could affect the vehicle while transferring the patient)  which can not be found in the public health service ambulances in the area. 

Excelan also incorporates the latest medical innovations. Their team of professional always keep up with the latest findings on the medical field. For example, Excelan’s doctors were pioneers in Spain on the Dr Hangover treatment.

And best of all, Excelan comes at a very affordable price. Excelan experts believe everybody should have access to the best medical services, so they provide the best treatments at a low price, all while keeping the higher quality standards.

Seeing a doctor at your own home

Visiting a doctor can be unpleasant sometimes. We need to travel to the doctor’s offices while being sick, and we often end up exposing ourselves to the illnesses of other patients. But Excelan Clinic offer their patients the services of the best GP doctor in Marbella.

Excelan offers the services of a GP doctor that will offer you whichever health services you need, wherever you need them. With a simple phone call, e-mail or whatsapp message, your doctor will visit you at your hotel, home, restaurant… The doctors are available 24/7, because your comfort and health should always comes first.

This option is especially recommended for tourists, since the staff is multilingual and this will help solving the possible language barriers. 

The professional team at Excelan has a lot of  experience and will make sure to give you a health service tailored to your needs. Because each patient is different and has different needs, opting out for a personalized service like the one provided by Excelan will always be the most intelligent option. 

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Key Methods for Identifying Hospital Staff

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In hospitals and other healthcare organisations, it’s vital that patients are able to identify members of staff. It’s also necessary for staff members to be able to identify each other and their roles. Different methods can be used to identify staff so that the people who need to know who they are can easily recognize them. Employees can use lots of visual cues that tell people about their role, their name, and which hospital they work for. These are some of the ways you can make sure your staff members are easily recognizable to anyone who needs to know who they are.

Uniforms

Uniforms are a great way to identify the staff in a hospital and to distinguish between people working in different roles. They are essential in hospitals for hygiene purposes, but they also serve an important purpose when it comes to making employees recognizable and trustworthy. Different uniforms help your staff to see who works in what role, and this can also be useful for patients, especially those who are staying long-term. Using different colors, patterns, and designs for different roles is helpful. You might also have logos or extra information printed or embroidered onto uniforms to provide further help.

Name Badges

It’s not just roles that are important for patients and staff members to know. People should also be able to identify employees at a hospital by name. Name badges are an easy way to do this, putting names and roles in a visible place. Name badges should be easy to clean so that they can be wiped clean regularly. They might not always be appropriate to wear, but it depends on the environment and the duties of the person. Although name badges can be a quick way to identify someone, they shouldn’t replace employees introducing themselves.

Official ID for Security

Security is another reason staff members may need to identify themselves. They will need to show identification when they enter the hospital and will likely need to use it to access certain areas of the hospital. When you provide ID for hospital staff, you also need to offer solutions for carrying and displaying it. A lanyard can make it easy for a member of staff to have their ID visible at all times. Some people might prefer to pin or clip their IDs to their clothing instead, especially if they don’t want to have something hanging around their neck.

Identifying Information

It can also be useful to provide information that helps patients to identify staff members. This could include providing materials that tell them how to identify people in different roles. You can provide them with a guide to what doctors, nurses, and other members of staff wear. It’s also helpful to explain what different roles mean. It’s not very useful for a patient to know which uniform a phlebotomist wears if they don’t know what a phlebotomist does.

Help your patients to identify hospital staff and your employees to identify each other by providing visual cues and useful information.

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How to Stay Healthy During Lockdown

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For most people, having to social distance and self-isolate because of a virus like COVID-19 is entirely new. Coronavirus has completely changed everyday life, and while everyone gets used to this new normal for however long it will last, it is important to ensure that you are looking after both your physical and mental health. Below are some tips for how you can stay healthy this difficult time:

Wash your hands

Hygiene is critical during this time. If you need to leave the house for any essential reasons, you must wash your hands frequently, especially if you are coming into contact with objects that other people have been in contact with. If you cannot wash your hands, try to use hand sanitizer. There are many hand sanitizer suppliers that are ensuring people have what they need.

Keep a routine

When you are suddenly unable to do the things that you would usually do during your day or week, it can be hard to stay in a healthy routine. It is very easy to mess up your sleeping pattern and get out of the habit of eating and drinking the right amounts of healthy food and drink. If you can, you should try to keep up with a routine that allows you to look after yourself properly. Try to wake up and go to bed at a similar time each day, shower or wash your face, and stay hydrated. You should also try to add something to your day that will help you relax and unwind, as it will make a big difference in how you feel.

Exercise when possible

Exercise is important for both your physical and mental health. This is a time where many people will be feeling more anxious and low than usual, so exercise can help to boost your mood. Staying at home will also mean that many people will be less active than usual. If you can go outside, try to go for walks or runs while maintaining social distance from others. If you are unable to go out, there are many workouts that you can find online that will ensure you stay active.

Stay in contact with friends

In many places, people shouldn’t meet up with friends and family outside of their household to stop the spread of coronavirus and to make the lives of healthcare workers easier. However, just because you have to stay away from people physically, doesn’t mean that you can’t keep in touch. We live in a time where technology can help you spend time with people you love without being physically present. You can talk to people other the telephone, stay up to date with your friend’s lives over social media, and facetime individuals or groups of people. You could organize a quiz once a week, start a book club, or watch films together. 

While it is crucial to keep in touch with people, it is also vital that you don’t believe everything that you read on social media. Ensure any news you read is from a reputable source.

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