Connect with us

Health

Electrospinning: the most advanced method of drug delivery

Published

on

electrospinning drug delivery

At the pharmaceutical level, the need to improve and refine the methods of drug delivery in the body is an area of great importance. Unlike people commonly assume, the effectiveness of a drug is not based solely on its composition, but on its method of application. 

This fact becomes clear if we look at the different presentations that a drug can have regarding ways of being supplied. Likewise, in the creation and composition of the drug for therapeutic use, the best and most efficient ways of providing the treatment are evaluated. 

The need for a drug delivery system that controls and directs the active pharmaceutical ingredients is becoming increasingly evident to achieve a decrease in the adverse side effects of treatment. An example, the need for control in the release of drug’s API into the body is what happened to cancer patients.

The treatment against cancer is hugely abrasive to the patient’s body, and therefore, its administration must be strongly dosed to decrease the intensity of the adverse side effects in the person. However, this also reduces the effectiveness of the treatment.

Delivery directed specifically to the area of the tumour, increasing the effectiveness of the drug and reducing adverse effects. Different methods of encapsulation have been tested but have marked limitations that allow only reduced variables to be controlled, such as the speed of drug delivery to the body once ingested.

The technology of electrospinning drug delivery breaks with the limitations of the previous methods of encapsulation achieving a controlled, directed and even programmed administration in the body. These benefits are due to the variety of materials that can be processed by electrospinning and the structural variations of the capsules, creating a significant variety for drug delivery in the body. 

What is electrospinning

Electrospinning is a fibre manufacturing technique. It works with electromagnetic principles by subjecting substances to high voltages to generate an electrostatic charge in the material that ends up resulting in the formation of the nanometer fibre as a product of electrostatic repulsion and surface tension of the solution.

Electrospinning has several uses because of its property of being able to produce a great variety of fibres with significant differences from each other without changing the method. Although it was initially used for the manufacture of textiles has expanded to other areas such as the manufacture of batteries. Even combine the fibres with building elements such as concrete because of its high strength due to mechanical stress that is subjected to the material in its manufacture.

However, it is in the area of nanomaterial production where its maximum utility is highlighted since nanomaterials present particular interactions depending on the material, and it is at such scale where cellular processes occur. This reason is why medicine, more specifically pharmacology, benefits greatly from such technology. 

In pharmacology, two types of drugs are sold (differentiated by application according to the fibre), dressings and tissues, both of which can be manufactured with the production of fibres derived from electrospinning. 

Differences between electrospinning and other methods for drug delivery

Notable drug encapsulation methods include spray-drying, freeze-drying and emulsification, which are easily recognizable on sight since most consumer drugs are distributed in such presentations. Each one has his own characteristics that make it more suitable for one type of drug than another, and each one has its limitations.

These methods are based on the preservation and dosage of the drug. Such as freeze-drying, which is the procedure of preservation by cryodrying, or emulsification, which consists of mixing immiscible liquids. While such forms of encapsulation work efficiently to preserve the drug and deliver it to the body, their reach goes there. 

Electrospinning systems for drugs delivery work in two ways, by mixing the bioactive compound, i.e. the drug with the polymer solution before applying electrospinning or after the creation of the fibre by coaxial processing. This method allows the efficient supply of the drug’s API as it benefits from the surface-volume area due to the dependence on the surface area where the application of nanofibers is favoured. 

The drug release profiles are highly adaptable to various applications by varying the solution of the polymer with which the nanofiber is created and controlling its area and volume. This process will allow the distribution of drugs that are released in response to chemical stimuli even hours after they have been ingested, that target specific areas if created with magnetic components, and even facilitate their production on a large scale since the other methods find it difficult to produce them massively.Innovation in fibre production in the pharmacological area will create more significant and more efficient scope for the medication of many diseases, improving the treatment of the patient and increasing its effectiveness. Electrospinning technology admits a wide range of natural and synthetic polymers for processing, in turn, lowers production costs, allowing for greater distribution of medicines to various sectors of the population.

Use your ← → (arrow) keys to browse

Student @ Advanced Digital Sciences Center, Singapore. Travelled to 30+ countries, passion for basketball.

Continue Reading
Comments

Health

Could Your House Be Harming Your Health?

Published

on

If you and your family members often suffer from the odd cough or cold, you might just think that it’s normal and the same for everyone. Does anyone in your household suffer from skin irritations or allergies? While most of these ailments aren’t too worrying, there are other, lesser-known issues that could be more harmful to you and your house could be to blame. Take a look at this list and see if you could do anything to create a happier, healthier household.

Methamphetamine Residue

Did you know that if the past residents or tenants or your home smoked meth then tiny particles will likely have land on the walls, floors, ceilings and any soft furnishings and these can contaminate a home? It’s probably not something you’ve thought about before, and most landlord or property managers will carry out rapid meth drug testing between owners or tenants to make sure that your property is safe. If you are buying a home, make sure that you have a Pre-purchase Meth Test and Inspection written into your conditions of sale just to be sure.  

Indoor leaks

A leak sounds harmless enough, but if a leak goes unnoticed and you don’t deal with it, it could cause mould to grow in your home which can be problematic for people prone to asthma and allergically-induced breathing problems. Make sure that you check pipes, closets, basements, and attics to ensure everywhere is dry and if you do find any leaky areas, clean and dry where the water has accumulated, and contact a plumber or roofer to fix the situation. 

Asbestos

If your home was built between 1920 and 1978, you might be exposed to asbestos, which was commonly used as a building and insulation material for homes in that era. It’s not the asbestos itself that is dangerous, but when it gets damaged as it may release asbestos fibres and become a health hazard. The best thing to do is to leave any asbestos materials alone. 

Dust

Dust a nuisance, it makes your home look unclean, and it gets everywhere, but not only that, but dust also carries irritating dust mites that can harm your nasal passage and eyes. According to research, dust mites put stress on your immune system, which then weakens over time. As well as this, dust only gets dustier and attracts dirt and particles from outside, which can contain pesticides and herbicides that are potentially toxic to your nervous system, and a recent study even linked dust to weight gain. To limit the amount of dust in your home, make sure that you vacuum regularly, don’t wear shoes in your house and even wipe the paws off your pets before they enter the house. Also, wash your sheets and towels weekly in hot water and make sure they’re thoroughly dried, regularly wash curtains, and stuffed animals. If you do have anyone in your home who suffers from allergies, then it’s a good idea to get covers for your mattresses and pillows which are designed to keep dust mites from getting through. 

Prev postNext post
Use your ← → (arrow) keys to browse

Continue Reading

Health

5 Applications To Improve Workplace Health & Safety

Published

on

workplace health

Keeping your employees safe and healthy at work is not just a legal requirement, but it’s essential to maintain productivity levels and achieve a strong company culture. This is particularly true of supporting the mental health of your staff. When you are in the process of revising your health and safety policies, these five apps may help to support your plans.

1. Fatigue Predictor Pro

Fatigue Predictor Pro is a ‘Fatigue Risk Management’ tool. Individuals can track their work and sleep and then access predicted fatigue levels on their duty roster. The application is perfect for companies to manage employee duty times and fatigue. It’s particularly recommended for construction or industrial roles (whereby fatigue when operating machinery is a concern). Staff members can send data to the cloud for the organization’s administrator to view. Fatigue Predictor is a handy tool to improve safety in the workplace.

2. Ergonomics

Ergonomics is a great app to improve health and wellness in the workplace. The application provides plenty of tips about stretching exercises and guidelines on how to set up your desk equipment ergonomically. The app encourages staff to take short breaks to stretch, including detailed instructions on various stretches, helping you perform the movements safely. Using the app, you can target certain areas of the body and assess your progress. Here you’ll also find plenty of advice about improving mental and physical health at work.

3. Wellspace

The Wellspace app was created to improve workplace wellbeing, no matter what your industry. The platform includes both an app and an online portal, to support staff members whenever they need it. Using Wellspace, employers can offer their staff the mental health support that they need. The application offers plenty of insightful content, including themes such as nutrition, sleep, mental health, and financial health. You can use the application to set health targets and measure progress.

4. 10 % Happier

10% Happier is the perfect app to enhance wellbeing and work towards positive mental health goals. The app provides hundreds of guided meditations on a wide variety of topics. A few of the topics include becoming more focused, parenting ideas, or dealing with anxiety. There’s a sleep section with specific sleep stories plus plenty of bite-sized activities on mindfulness. These brief meditations and ‘mindful moments’ are super easy to squeeze in on a work break!

5. NIOSH Lift Calculator 

The NIOSH Lift Calculator app can help you find ergonomic solutions and help you to safely handle heavy loads. First, you have to describe the lifting conditions, and from here, the app will provide you with a recommended weight limit. You can use the app to calculate multiple lifting or single lifting tasks. To protect workers from back problems and physical stress, The NIOSH app recommends a lifting index of CLI (or less).

Simple protocol, such as wearing the right PPE, is another way to maintain workplace safety levels. Workwear Hub provides a great range of steel blue safety boots. For more details, visit website.

Use your ← → (arrow) keys to browse

Continue Reading

Health

Feeling the Pressure of Prescriptions? Read this Now!

Published

on

Prescription medicines

Healthcare costs have been rising at runaway rates for the past few decades. In 2018, Americans spent nearly $3.7 trillion on health care, reports Fortune Magazine. That’s more than the GDP of the United Kingdom, Mexico, Spain!

This is increasingly a big problem for a nation that now spends significantly more as a country, and per person, than any other developed economy. While lawmakers and society will have to figure out a way to control these skyrocketing sums, on the individual level, it’s important for everyone to do as much as they can to keep their own costs in check — without sacrificing the care they need.

It isn’t always easy. One area where we continue to see higher expense is on pharmaceuticals. More and more people are now taking prescription drugs. This is good in many ways. They allow people to live with less pain, fewer symptoms, better mobility, and so much more.

But it also means that so many people have to find a way to pay for their sometimes expensive prescriptions. This makes getting the right coverage and getting the best advice from doctors more important than ever.

Nobody wants to put their wallet ahead of their health. And with the right strategy, you can hopefully avoid ever facing such a difficult situation. Try this advice and you can likely find savings for years to come.

1. Go With Generic Medication

Pharma companies invest billions in research and development. This pays off greatly when they come up with a great new drug that is used by many people. But the patent on that pill only lasts so long. Once it expires, anyone can make the same medicine and this naturally cuts the price.

This means that you don’t need to pay more for the label. Many people prefer to pay more for the name they know. But in many cases, the generic is literally the exact same thing — just with a lower price tag. Talk to your doctor and see if you can find some savings by going generic.

2. Fill Your Script in Bulk

There can be extra costs for pharmaceuticals each time you fill a prescription. Specifically, you might be on the hook for a co-pay whenever you get a new bottle. So if you only get 30 pills at a time for the month, that means 12 extra charges per year. In some cases, you may be able to instead get 90 pills. Not only do you now pay just 4 times per year, but it saves you a lot hassle.

“Buying in bulk” can also pay off if you get larger doses in some cases. Certain pills can just be cut in half, so getting 30 pills of 20 mgs then splitting them at home is the equivalent of 60 pills of 10 mgs. Doing this effectively accomplishes the same result if your doctor is on board.

3. Understand Your Plan

The more you know about your healthcare coverage, the more you can benefit. A lot of plans allow people wider access to doctors and clinics than they realize — and at very low costs. All it takes is understanding your policy a bit better to take advantage.

Medicare is a great example. It has been around for so long, and most people have relatives or friends who use it. So they think they know what it does and does not cover. But the popularity and availability of supplemental coverage has grown significantly over the decades, with Medicare Part D becoming a particularly great option. Because it makes many prescription drugs free — for such a small extra premium — it is one of the best ways to protect your health and your bank account.

Great Health Anyone Can Afford

The right prescriptions can be a life saver. We have so many options and ways to treat our issues nowadays, and it really is amazing for anyone who is suffering or wants to prevent a disease from progressing.

But it sure does cost a lot. That’s why you need to be smart and employ strategies like going generic, filling your prescription in bulk, and really understanding all the benefits available in your plan. 

When it comes to medication, you want to get exactly what you need at the lowest possible cost. You can’t afford to make sacrifices to your health. And with a few simple tips, you really will be able to afford whatever you need.

Use your ← → (arrow) keys to browse

Continue Reading

Trending